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Results depend heavily on baseline body composition, dietary adherence, exercise programming, sleep quality, stress management, genetic factors, and protocol compliance
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A detailed analysis of the antiobesity action of fenfluramine disclosed that it directly activates hypothalamic POMC neurons through 5-hydroxytryptamine 2C (5-HT2C) receptors that are expressed on a majority of these cells [80]
Another small, randomized, double-blind trial in 93 individuals with low vitamin D status found no additional benefit of B-vitamin supplementation (50 mg/day of vitamin B6, 0.5 mg/day of folic acid, and 0.5 mg/day of vitamin B 12 ) on markers of bone health over a one-year period beyond that associated with vitamin D and calcium supplementation
Each component has real preclinical support, and MOTS-c in particular has a solid animal record
This combination can optimize body composition rather than only weight loss
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